Plant Transcription Factor Database
Previous version: v3.0
Nicotiana tomentosiformis
Species TF ID Description
XP_009586720.1MIKC_MADS family protein
XP_009586721.1MIKC_MADS family protein
XP_009586722.1MIKC_MADS family protein
XP_009586723.1MIKC_MADS family protein
XP_009588019.1MIKC_MADS family protein
XP_009588903.1MIKC_MADS family protein
XP_009588907.1MIKC_MADS family protein
XP_009589584.1MIKC_MADS family protein
XP_009589591.1MIKC_MADS family protein
XP_009589597.1MIKC_MADS family protein
XP_009591403.1MIKC_MADS family protein
XP_009592797.1MIKC_MADS family protein
XP_009593700.1MIKC_MADS family protein
XP_009595408.1MIKC_MADS family protein
XP_009595409.1MIKC_MADS family protein
XP_009595410.1MIKC_MADS family protein
XP_009595701.1MIKC_MADS family protein
XP_009598871.1MIKC_MADS family protein
XP_009599024.1MIKC_MADS family protein
XP_009599025.1MIKC_MADS family protein
XP_009600809.1MIKC_MADS family protein
XP_009603844.1MIKC_MADS family protein
XP_009605879.1MIKC_MADS family protein
XP_009606375.1MIKC_MADS family protein
XP_009606376.1MIKC_MADS family protein
XP_009606377.1MIKC_MADS family protein
XP_009606378.1MIKC_MADS family protein
XP_009607136.1MIKC_MADS family protein
XP_009608298.1MIKC_MADS family protein
XP_009608306.1MIKC_MADS family protein
XP_009608310.1MIKC_MADS family protein
XP_009608317.1MIKC_MADS family protein
XP_009608611.1MIKC_MADS family protein
XP_009608613.1MIKC_MADS family protein
XP_009608614.1MIKC_MADS family protein
XP_009608615.1MIKC_MADS family protein
XP_009608616.1MIKC_MADS family protein
XP_009608617.1MIKC_MADS family protein
XP_009608638.1MIKC_MADS family protein
XP_009609340.1MIKC_MADS family protein
XP_009612078.1MIKC_MADS family protein
XP_009612079.1MIKC_MADS family protein
XP_009612439.1MIKC_MADS family protein
XP_009612441.1MIKC_MADS family protein
XP_009612442.1MIKC_MADS family protein
XP_009612621.1MIKC_MADS family protein
XP_009615088.1MIKC_MADS family protein
XP_009615089.1MIKC_MADS family protein
XP_009615091.1MIKC_MADS family protein
XP_009615311.1MIKC_MADS family protein
XP_009615312.1MIKC_MADS family protein
XP_009615313.1MIKC_MADS family protein
XP_009616464.1MIKC_MADS family protein
XP_009616465.1MIKC_MADS family protein
XP_009616788.1MIKC_MADS family protein
XP_009616789.1MIKC_MADS family protein
XP_009616790.1MIKC_MADS family protein
XP_009616791.1MIKC_MADS family protein
XP_009616792.1MIKC_MADS family protein
XP_009616793.1MIKC_MADS family protein
XP_009617463.1MIKC_MADS family protein
XP_009617464.1MIKC_MADS family protein
XP_009617465.1MIKC_MADS family protein
XP_009617466.1MIKC_MADS family protein
XP_009617467.1MIKC_MADS family protein
XP_009617468.1MIKC_MADS family protein
XP_009617469.1MIKC_MADS family protein
XP_009618485.1MIKC_MADS family protein
XP_009618491.1MIKC_MADS family protein
XP_009618495.1MIKC_MADS family protein
XP_009618745.1MIKC_MADS family protein
XP_009619172.1MIKC_MADS family protein
XP_009619475.1MIKC_MADS family protein
XP_009622386.1MIKC_MADS family protein
XP_009623629.1MIKC_MADS family protein
XP_009623630.1MIKC_MADS family protein
XP_009623750.1MIKC_MADS family protein
XP_009625300.1MIKC_MADS family protein
XP_009625850.1MIKC_MADS family protein
XP_009625854.1MIKC_MADS family protein
XP_009626499.1MIKC_MADS family protein
XP_009627161.1MIKC_MADS family protein
XP_009627162.1MIKC_MADS family protein
XP_009627163.1MIKC_MADS family protein
XP_009627164.1MIKC_MADS family protein
XP_009629660.1MIKC_MADS family protein
XP_009629661.1MIKC_MADS family protein
XP_009631749.1MIKC_MADS family protein
XP_009631750.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513